Basic Info.

Product Description

Abstract

Citicoline, also known as cytidine 5'-diphosphocholine (CDP-choline), is a naturally occurring compound that serves as a critical intermediate in the biosynthesis of structural phospholipids in cell membranes, particularly in the brain.

Description

• Chemical Identity: It is a mononucleotide composed of ribose, cytosine, pyrophosphate, and choline.
• Physiological Role: Naturally present in human and animal cells, especially in organs, it is an essential precursor for the synthesis of phosphatidylcholine, a major component of neuronal membranes.

Function

Citicoline functions primarily as a neuroprotective and nootropic agent through several mechanisms:

• Membrane Repair: It supports the synthesis of phosphatidylcholine and other phospholipids (like sphingomyelin and cardiolipin), which are essential for maintaining the integrity and fluidity of brain cell membranes.
• Neurotransmitter Support: It increases levels of key brain chemicals, including acetylcholine (vital for memory), dopamine, and norepinephrine.
• Brain Energy: It enhances cerebral metabolism and increases the production and utilization of energy (ATP) within brain cells.
• Neuroprotection: It helps block the activation of phospholipase A2 (reducing inflammation) and lowers levels of glutamate, a neurotransmitter that can cause damage during low oxygen conditions like ischemia.

Application

Citicoline is applied in both clinical and supplemental contexts, though clinical results for some acute conditions remain mixed.

• Cognitive Enhancement: Used by healthy individuals to improve attention, focus, and memory, particularly in those experiencing age-related cognitive decline.
• Neurodegenerative Diseases:
  • Alzheimer's & Dementia: Investigated for its potential to slow disease progression and improve cognitive assessment scores.
  • Parkinson's Disease: Used as an adjunctive therapy with levodopa to improve motor symptoms and potentially reduce the required dose of levodopa.
• Ophthalmology: Studied for its benefits in glaucoma (improving visual function and protecting retinal ganglion cells), amblyopia (lazy eye), and non-arteritic ischemic optic neuropathy.

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Our Advantages

About Us

We focus on cosmetic active ingredients, bioactive materials, and plant extracts. In cosmetics, we develop high-purity, high-stability and skin-friendly active ingredients with anti-aging, moisturizing, repairing and brightening effects through biosynthesis, meeting the demand for natural and efficient raw materials in the global beauty industry. In bioactive raw materials, we provide safe and stable products for functional food, health care and biomedical fields. In plant extracts, we strictly develop and produce high-quality APIs, supporting drug R&D and human health.

In addition, we have strong capabilities in customized peptide synthesis. We have a professional R&D team and an advanced synthesis platform, providing one-stop customized services covering linear peptides, complex cyclic peptides, peptide encapsulation and modification.

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